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ELSEA, SARAH
One or more keywords matched the following items that are connected to
ELSEA, SARAH
Item Type
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Academic Article
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.
Academic Article
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
Academic Article
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes.
Academic Article
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
Academic Article
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.
Academic Article
Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity.
Academic Article
Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.
Concept
DNA Topoisomerases, Type II
Concept
DNA Topoisomerases, Type I
Search Criteria
DNA Topoisomerases